MaghrebDataLibMedV2, Main, Exploration, bibRecord, 000579

NU-6027 Inhibits Growth of Mycobacterium tuberculosis by Targeting Protein Kinase D and Protein Kinase G

Identifieur interne : 000579 ( Main/Exploration ); précédent : 000578; suivant : 000580

NU-6027 Inhibits Growth of Mycobacterium tuberculosis by Targeting Protein Kinase D and Protein Kinase G

Auteurs : Saqib Kidwai [Inde] ; Rania Bouzeyen [Tunisie] ; Sohini Chakraborti [Inde] ; Neha Khare [Inde] ; Sumana Das [Inde] ; Tannu Priya Gosain [Inde] ; Assirbad Behura [Inde] ; Chhuttan Lal Meena [Inde] ; Rohan Dhiman [Inde] ; Makram Essafi [Tunisie] ; Avinash Bajaj [Inde] ; Deepak Kumar Saini [Inde] ; Narayanaswamy Srinivasan [Inde] ; Dinesh Mahajan [Inde] ; Ramandeep Singh [Inde]

Source :

Antimicrobial Agents and Chemotherapy [ 0066-4804 ] ; 2019.

RBID : PMC:6709498

Descripteurs français

English descriptors

KwdEn :
- Antitubercular Agents (chemistry), Antitubercular Agents (pharmacology), Apoptosis Regulatory Proteins (agonists), Apoptosis Regulatory Proteins (genetics), Apoptosis Regulatory Proteins (metabolism), Bacterial Proteins (antagonists & inhibitors), Bacterial Proteins (chemistry), Bacterial Proteins (genetics), Bacterial Proteins (metabolism), Binding Sites (MeSH), Gene Expression Regulation (MeSH), High-Throughput Screening Assays (MeSH), Host-Pathogen Interactions (MeSH), Macrophages (metabolism), Macrophages (microbiology), Microbial Sensitivity Tests (MeSH), Molecular Docking Simulation (MeSH), Mycobacterium bovis (drug effects), Mycobacterium bovis (enzymology), Mycobacterium bovis (genetics), Mycobacterium bovis (growth & development), Mycobacterium tuberculosis (drug effects), Mycobacterium tuberculosis (enzymology), Mycobacterium tuberculosis (genetics), Mycobacterium tuberculosis (growth & development), Nitroso Compounds (chemistry), Nitroso Compounds (pharmacology), Protein Binding (MeSH), Protein Interaction Domains and Motifs (MeSH), Protein Kinase C (antagonists & inhibitors), Protein Kinase C (chemistry), Protein Kinase C (genetics), Protein Kinase C (metabolism), Protein Kinase Inhibitors (chemistry), Protein Kinase Inhibitors (pharmacology), Protein Structure, Secondary (MeSH), Protein-Serine-Threonine Kinases (antagonists & inhibitors), Protein-Serine-Threonine Kinases (chemistry), Protein-Serine-Threonine Kinases (genetics), Protein-Serine-Threonine Kinases (metabolism), Pyrimidines (chemistry), Pyrimidines (pharmacology), Small Molecule Libraries (chemistry), Small Molecule Libraries (pharmacology).
MESH :
- chemical , agonists : Apoptosis Regulatory Proteins.
- chemical , antagonists & inhibitors : Bacterial Proteins, Protein Kinase C, Protein-Serine-Threonine Kinases.
- chemical , chemistry : Antitubercular Agents, Bacterial Proteins, Nitroso Compounds, Protein Kinase C, Protein Kinase Inhibitors, Protein-Serine-Threonine Kinases, Pyrimidines, Small Molecule Libraries.
- chemical , genetics : Apoptosis Regulatory Proteins, Bacterial Proteins, Protein Kinase C, Protein-Serine-Threonine Kinases.
- chemical , metabolism : Apoptosis Regulatory Proteins, Bacterial Proteins, Protein Kinase C, Protein-Serine-Threonine Kinases.
- chemical , pharmacology : Antitubercular Agents, Nitroso Compounds, Protein Kinase Inhibitors, Pyrimidines, Small Molecule Libraries.
- drug effects : Mycobacterium bovis, Mycobacterium tuberculosis.
- enzymology : Mycobacterium bovis, Mycobacterium tuberculosis.
- genetics : Mycobacterium bovis, Mycobacterium tuberculosis.
- growth & development : Mycobacterium bovis, Mycobacterium tuberculosis.
- metabolism : Macrophages.
- microbiology : Macrophages.
- Binding Sites, Gene Expression Regulation, High-Throughput Screening Assays, Host-Pathogen Interactions, Microbial Sensitivity Tests, Molecular Docking Simulation, Protein Binding, Protein Interaction Domains and Motifs, Protein Structure, Secondary.

Abstract

Tuberculosis (TB) is a global health concern, and this situation has further worsened due to the emergence of drug-resistant strains and the failure of BCG vaccine to impart protection. There is an imperative need to develop highly sensitive, specific diagnostic tools, novel therapeutics, and vaccines for the eradication of TB. In the present study, a chemical screen of a pharmacologically active compound library was performed to identify antimycobacterial compounds.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709498

DOI: 10.1128/AAC.00996-19
PubMed: 31285226
PubMed Central: 6709498

Affiliations:

Inde, Tunisie

Le document en format XML

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 by Targeting Protein Kinase D and Protein Kinase G</title>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">NU-6027 Inhibits Growth of <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content>
 by Targeting Protein Kinase D and Protein Kinase G</title>
<author><name sortKey="Kidwai, Saqib" sort="Kidwai, Saqib" uniqKey="Kidwai S" first="Saqib" last="Kidwai">Saqib Kidwai</name>
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<author><name sortKey="Chakraborti, Sohini" sort="Chakraborti, Sohini" uniqKey="Chakraborti S" first="Sohini" last="Chakraborti">Sohini Chakraborti</name>
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<author><name sortKey="Das, Sumana" sort="Das, Sumana" uniqKey="Das S" first="Sumana" last="Das">Sumana Das</name>
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<author><name sortKey="Priya Gosain, Tannu" sort="Priya Gosain, Tannu" uniqKey="Priya Gosain T" first="Tannu" last="Priya Gosain">Tannu Priya Gosain</name>
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<author><name sortKey="Behura, Assirbad" sort="Behura, Assirbad" uniqKey="Behura A" first="Assirbad" last="Behura">Assirbad Behura</name>
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<author><name sortKey="Meena, Chhuttan Lal" sort="Meena, Chhuttan Lal" uniqKey="Meena C" first="Chhuttan Lal" last="Meena">Chhuttan Lal Meena</name>
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<author><name sortKey="Essafi, Makram" sort="Essafi, Makram" uniqKey="Essafi M" first="Makram" last="Essafi">Makram Essafi</name>
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<author><name sortKey="Bajaj, Avinash" sort="Bajaj, Avinash" uniqKey="Bajaj A" first="Avinash" last="Bajaj">Avinash Bajaj</name>
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</nlm:aff>
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<author><name sortKey="Saini, Deepak Kumar" sort="Saini, Deepak Kumar" uniqKey="Saini D" first="Deepak Kumar" last="Saini">Deepak Kumar Saini</name>
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<author><name sortKey="Srinivasan, Narayanaswamy" sort="Srinivasan, Narayanaswamy" uniqKey="Srinivasan N" first="Narayanaswamy" last="Srinivasan">Narayanaswamy Srinivasan</name>
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<author><name sortKey="Mahajan, Dinesh" sort="Mahajan, Dinesh" uniqKey="Mahajan D" first="Dinesh" last="Mahajan">Dinesh Mahajan</name>
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</nlm:aff>
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<author><name sortKey="Singh, Ramandeep" sort="Singh, Ramandeep" uniqKey="Singh R" first="Ramandeep" last="Singh">Ramandeep Singh</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Tuberculosis Research Laboratory, Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India</addr-line>
</nlm:aff>
<country xml:lang="fr">Inde</country>
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</affiliation>
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<series><title level="j">Antimicrobial Agents and Chemotherapy</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antitubercular Agents (chemistry)</term>
<term>Antitubercular Agents (pharmacology)</term>
<term>Apoptosis Regulatory Proteins (agonists)</term>
<term>Apoptosis Regulatory Proteins (genetics)</term>
<term>Apoptosis Regulatory Proteins (metabolism)</term>
<term>Bacterial Proteins (antagonists & inhibitors)</term>
<term>Bacterial Proteins (chemistry)</term>
<term>Bacterial Proteins (genetics)</term>
<term>Bacterial Proteins (metabolism)</term>
<term>Binding Sites (MeSH)</term>
<term>Gene Expression Regulation (MeSH)</term>
<term>High-Throughput Screening Assays (MeSH)</term>
<term>Host-Pathogen Interactions (MeSH)</term>
<term>Macrophages (metabolism)</term>
<term>Macrophages (microbiology)</term>
<term>Microbial Sensitivity Tests (MeSH)</term>
<term>Molecular Docking Simulation (MeSH)</term>
<term>Mycobacterium bovis (drug effects)</term>
<term>Mycobacterium bovis (enzymology)</term>
<term>Mycobacterium bovis (genetics)</term>
<term>Mycobacterium bovis (growth & development)</term>
<term>Mycobacterium tuberculosis (drug effects)</term>
<term>Mycobacterium tuberculosis (enzymology)</term>
<term>Mycobacterium tuberculosis (genetics)</term>
<term>Mycobacterium tuberculosis (growth & development)</term>
<term>Nitroso Compounds (chemistry)</term>
<term>Nitroso Compounds (pharmacology)</term>
<term>Protein Binding (MeSH)</term>
<term>Protein Interaction Domains and Motifs (MeSH)</term>
<term>Protein Kinase C (antagonists & inhibitors)</term>
<term>Protein Kinase C (chemistry)</term>
<term>Protein Kinase C (genetics)</term>
<term>Protein Kinase C (metabolism)</term>
<term>Protein Kinase Inhibitors (chemistry)</term>
<term>Protein Kinase Inhibitors (pharmacology)</term>
<term>Protein Structure, Secondary (MeSH)</term>
<term>Protein-Serine-Threonine Kinases (antagonists & inhibitors)</term>
<term>Protein-Serine-Threonine Kinases (chemistry)</term>
<term>Protein-Serine-Threonine Kinases (genetics)</term>
<term>Protein-Serine-Threonine Kinases (metabolism)</term>
<term>Pyrimidines (chemistry)</term>
<term>Pyrimidines (pharmacology)</term>
<term>Small Molecule Libraries (chemistry)</term>
<term>Small Molecule Libraries (pharmacology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Antituberculeux (composition chimique)</term>
<term>Antituberculeux (pharmacologie)</term>
<term>Bibliothèques de petites molécules (composition chimique)</term>
<term>Bibliothèques de petites molécules (pharmacologie)</term>
<term>Composés nitrosés (composition chimique)</term>
<term>Composés nitrosés (pharmacologie)</term>
<term>Inhibiteurs de protéines kinases (composition chimique)</term>
<term>Inhibiteurs de protéines kinases (pharmacologie)</term>
<term>Interactions hôte-pathogène (MeSH)</term>
<term>Liaison aux protéines (MeSH)</term>
<term>Macrophages (microbiologie)</term>
<term>Macrophages (métabolisme)</term>
<term>Motifs et domaines d'intéraction protéique (MeSH)</term>
<term>Mycobacterium bovis (croissance et développement)</term>
<term>Mycobacterium bovis (effets des médicaments et des substances chimiques)</term>
<term>Mycobacterium bovis (enzymologie)</term>
<term>Mycobacterium bovis (génétique)</term>
<term>Mycobacterium tuberculosis (croissance et développement)</term>
<term>Mycobacterium tuberculosis (effets des médicaments et des substances chimiques)</term>
<term>Mycobacterium tuberculosis (enzymologie)</term>
<term>Mycobacterium tuberculosis (génétique)</term>
<term>Protein-Serine-Threonine Kinases (antagonistes et inhibiteurs)</term>
<term>Protein-Serine-Threonine Kinases (composition chimique)</term>
<term>Protein-Serine-Threonine Kinases (génétique)</term>
<term>Protein-Serine-Threonine Kinases (métabolisme)</term>
<term>Protéine kinase C (antagonistes et inhibiteurs)</term>
<term>Protéine kinase C (composition chimique)</term>
<term>Protéine kinase C (génétique)</term>
<term>Protéine kinase C (métabolisme)</term>
<term>Protéines bactériennes (antagonistes et inhibiteurs)</term>
<term>Protéines bactériennes (composition chimique)</term>
<term>Protéines bactériennes (génétique)</term>
<term>Protéines bactériennes (métabolisme)</term>
<term>Protéines régulatrices de l'apoptose (agonistes)</term>
<term>Protéines régulatrices de l'apoptose (génétique)</term>
<term>Protéines régulatrices de l'apoptose (métabolisme)</term>
<term>Pyrimidines (composition chimique)</term>
<term>Pyrimidines (pharmacologie)</term>
<term>Régulation de l'expression des gènes (MeSH)</term>
<term>Simulation de docking moléculaire (MeSH)</term>
<term>Sites de fixation (MeSH)</term>
<term>Structure secondaire des protéines (MeSH)</term>
<term>Tests de criblage à haut débit (MeSH)</term>
<term>Tests de sensibilité microbienne (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="agonists" xml:lang="en"><term>Apoptosis Regulatory Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Bacterial Proteins</term>
<term>Protein Kinase C</term>
<term>Protein-Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antitubercular Agents</term>
<term>Bacterial Proteins</term>
<term>Nitroso Compounds</term>
<term>Protein Kinase C</term>
<term>Protein Kinase Inhibitors</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Pyrimidines</term>
<term>Small Molecule Libraries</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apoptosis Regulatory Proteins</term>
<term>Bacterial Proteins</term>
<term>Protein Kinase C</term>
<term>Protein-Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Apoptosis Regulatory Proteins</term>
<term>Bacterial Proteins</term>
<term>Protein Kinase C</term>
<term>Protein-Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antitubercular Agents</term>
<term>Nitroso Compounds</term>
<term>Protein Kinase Inhibitors</term>
<term>Pyrimidines</term>
<term>Small Molecule Libraries</term>
</keywords>
<keywords scheme="MESH" qualifier="agonistes" xml:lang="fr"><term>Protéines régulatrices de l'apoptose</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Protein-Serine-Threonine Kinases</term>
<term>Protéine kinase C</term>
<term>Protéines bactériennes</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Antituberculeux</term>
<term>Bibliothèques de petites molécules</term>
<term>Composés nitrosés</term>
<term>Inhibiteurs de protéines kinases</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Protéine kinase C</term>
<term>Protéines bactériennes</term>
<term>Pyrimidines</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Mycobacterium bovis</term>
<term>Mycobacterium tuberculosis</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Mycobacterium bovis</term>
<term>Mycobacterium tuberculosis</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Mycobacterium bovis</term>
<term>Mycobacterium tuberculosis</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Mycobacterium bovis</term>
<term>Mycobacterium tuberculosis</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Mycobacterium bovis</term>
<term>Mycobacterium tuberculosis</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Mycobacterium bovis</term>
<term>Mycobacterium tuberculosis</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Mycobacterium bovis</term>
<term>Mycobacterium tuberculosis</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Mycobacterium bovis</term>
<term>Mycobacterium tuberculosis</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Protéine kinase C</term>
<term>Protéines bactériennes</term>
<term>Protéines régulatrices de l'apoptose</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Macrophages</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Protéine kinase C</term>
<term>Protéines bactériennes</term>
<term>Protéines régulatrices de l'apoptose</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antituberculeux</term>
<term>Bibliothèques de petites molécules</term>
<term>Composés nitrosés</term>
<term>Inhibiteurs de protéines kinases</term>
<term>Pyrimidines</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Binding Sites</term>
<term>Gene Expression Regulation</term>
<term>High-Throughput Screening Assays</term>
<term>Host-Pathogen Interactions</term>
<term>Microbial Sensitivity Tests</term>
<term>Molecular Docking Simulation</term>
<term>Protein Binding</term>
<term>Protein Interaction Domains and Motifs</term>
<term>Protein Structure, Secondary</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Interactions hôte-pathogène</term>
<term>Liaison aux protéines</term>
<term>Motifs et domaines d'intéraction protéique</term>
<term>Régulation de l'expression des gènes</term>
<term>Simulation de docking moléculaire</term>
<term>Sites de fixation</term>
<term>Structure secondaire des protéines</term>
<term>Tests de criblage à haut débit</term>
<term>Tests de sensibilité microbienne</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Tuberculosis (TB) is a global health concern, and this situation has further worsened due to the emergence of drug-resistant strains and the failure of BCG vaccine to impart protection. There is an imperative need to develop highly sensitive, specific diagnostic tools, novel therapeutics, and vaccines for the eradication of TB. In the present study, a chemical screen of a pharmacologically active compound library was performed to identify antimycobacterial compounds.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Inde</li>
<li>Tunisie</li>
</country>
</list>
<tree><country name="Inde"><noRegion><name sortKey="Kidwai, Saqib" sort="Kidwai, Saqib" uniqKey="Kidwai S" first="Saqib" last="Kidwai">Saqib Kidwai</name>
</noRegion>
<name sortKey="Bajaj, Avinash" sort="Bajaj, Avinash" uniqKey="Bajaj A" first="Avinash" last="Bajaj">Avinash Bajaj</name>
<name sortKey="Behura, Assirbad" sort="Behura, Assirbad" uniqKey="Behura A" first="Assirbad" last="Behura">Assirbad Behura</name>
<name sortKey="Chakraborti, Sohini" sort="Chakraborti, Sohini" uniqKey="Chakraborti S" first="Sohini" last="Chakraborti">Sohini Chakraborti</name>
<name sortKey="Das, Sumana" sort="Das, Sumana" uniqKey="Das S" first="Sumana" last="Das">Sumana Das</name>
<name sortKey="Dhiman, Rohan" sort="Dhiman, Rohan" uniqKey="Dhiman R" first="Rohan" last="Dhiman">Rohan Dhiman</name>
<name sortKey="Khare, Neha" sort="Khare, Neha" uniqKey="Khare N" first="Neha" last="Khare">Neha Khare</name>
<name sortKey="Mahajan, Dinesh" sort="Mahajan, Dinesh" uniqKey="Mahajan D" first="Dinesh" last="Mahajan">Dinesh Mahajan</name>
<name sortKey="Meena, Chhuttan Lal" sort="Meena, Chhuttan Lal" uniqKey="Meena C" first="Chhuttan Lal" last="Meena">Chhuttan Lal Meena</name>
<name sortKey="Priya Gosain, Tannu" sort="Priya Gosain, Tannu" uniqKey="Priya Gosain T" first="Tannu" last="Priya Gosain">Tannu Priya Gosain</name>
<name sortKey="Saini, Deepak Kumar" sort="Saini, Deepak Kumar" uniqKey="Saini D" first="Deepak Kumar" last="Saini">Deepak Kumar Saini</name>
<name sortKey="Singh, Ramandeep" sort="Singh, Ramandeep" uniqKey="Singh R" first="Ramandeep" last="Singh">Ramandeep Singh</name>
<name sortKey="Srinivasan, Narayanaswamy" sort="Srinivasan, Narayanaswamy" uniqKey="Srinivasan N" first="Narayanaswamy" last="Srinivasan">Narayanaswamy Srinivasan</name>
</country>
<country name="Tunisie"><noRegion><name sortKey="Bouzeyen, Rania" sort="Bouzeyen, Rania" uniqKey="Bouzeyen R" first="Rania" last="Bouzeyen">Rania Bouzeyen</name>
</noRegion>
<name sortKey="Essafi, Makram" sort="Essafi, Makram" uniqKey="Essafi M" first="Makram" last="Essafi">Makram Essafi</name>
</country>
</tree>
</affiliations>
</record>

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NU-6027 Inhibits Growth of Mycobacterium tuberculosis by Targeting Protein Kinase D and Protein Kinase G

NU-6027 Inhibits Growth of Mycobacterium tuberculosis by Targeting Protein Kinase D and Protein Kinase G

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